Software : Tutorials
Software : Tutorials
The links below provide access to a number of our written tutorials on the design, conduct, monitoring, and analysis of clinical trials. These tutorials are more directed toward the use of the software than to explanations of the theory and methods behind sequential sampling. For the latter see our tutorials on the Learning webpages.
These tutorials are organized into the following categories (a single tutorial may appear in multiple categories):
•Getting Started in RCTdesign including an overview of specification of simple designs, the interpretation of the standard output, and the generation of useful plots.
•Probability Models including description of distribution-free inference on means, geometric means, proportions, odds, and hazards; special issues when using time to event (survival) endpoints, and special issues when using longitudinal endpoints.
•Specification of Hypotheses
•Nonbinding Futility Boundaries
•Sample Size Computation
•Calculating Subject Accrual Needs in a Time to Event Analysis
•Sequential Sampling
•The Unified Family of Group Sequential Stopping Rules
•Specification of Error Spending Families
•Use of Constrained Boundaries: Maxima, Minima, Exact
•Computing Operating Characteristics: Type I Error, Power, Stopping Probabilities
•Simulating Clinical Trials in RCTdesign
•Inference in the Presence of a Stopping Rule
•Bayesian Evaluation of a Stopping Rule
•Monitoring a Clinical Trial: Flexible Implementation of a Sequential Sampling Plan
•Adaptive Modification of a Maximal Sample Size
•Advanced Functionality
RCTdesign Documents: