Technical Reports : Bayesian Inference

 
 

A comparison of parametric and coarsened Bayesian interval estimation in the presence of a known mean-variance relationship.

  1. Summary: A discussion of distribution-free Bayesian inference in such a way as to accomodate a mean-variance relationship.

  2. Ref: Koprowicz K, Emerson SS, Hoff P, (BEPress) (2005).



Bayesian evaluation of group sequential clinical trial designs.

  1. Summary: A tutorial on the various Bayesian operating characteristics of interest when choosing a group sequential stopping rule.

  2. Ref: Emerson SS, Kittelson JM, Gillen DL, Statistics in Medicine 26: 1421-1449 (2007).



Evaluation of Strategies for the Phase II to Phase III Progression in Treatment Discovery

  1. Summary:  Brittany J. Sanchez Thesis: An investigation of the importance of well-planned progression from Phase II to Phase III RCT in order to ensure a sufficiently low false positive rate of adopting ineffective treatments (a low type 1 error), a sufficiently high probability of adopting truly effective treatments (a high statistical power), and a sufficiently high probability that adopted treatments will be truly effective (a high positive predictive value). Also investigated in the bias associated with early termination of group sequential RCT.

  2. Ref: Sanchez BJ (2014)

 


Technical Report Topics:


  1. •Probability models

  2. •General RCT methods

  3. •Noninferiority trials

  4. •Stopping rules

  5. •Adaptive methods

  6. •Implementation

  7. •Frequentist inference

  8. •Bayesian methods

  9. •Survival outcomes

  10. •Longitudinal outcomes

  11. •Medical diagnosis

  12. •Missing data

  13. •Software