Technical Reports : Noninferiority Trials

 
 

Bio-creep in non-inferiority clinical trials.

  1. Summary:  An investigation of the degree to which successive non-inferiority clinical trials might lead to the adoption of ineffective treatments.

  2. Ref: Everson-Steward SP, Emerson SS, Statistics in Medicine (2010)

 


Technical Report Topics:


  1. •Probability models

  2. •General RCT methods

  3. •Noninferiority trials

  4. •Stopping rules

  5. •Adaptive methods

  6. •Implementation

  7. •Frequentist inference

  8. •Bayesian methods

  9. •Survival outcomes

  10. •Longitudinal outcomes

  11. •Medical diagnosis

  12. •Missing data

  13. •Software